Publications

M. Wright, M. A. Azhar, A. Kamal & A. D. Miller, Syntheses of stable, synthetic diadenosine polyphosphate analogues using recombinant histidine-tagged lysyl tRNA synthetase (LysU), Bioorg. Med. Chem. Lett., 2014, 24, 2346

M. A. Azhar, M. Wright, A. Kamal, J. Nagy & A. D. Miller, Biotin-c10-AppCH2ppA is an effective new chemical proteomics probe for diadenosine polyphosphate binding proteins, Bioorg. Med. Chem. Lett., 2014, 24, 2928

Thanou M. & Gedroyc W, MRI-Guided Focused Ultrasound as a New Method of Drug Delivery. J Drug Deliv. 2013, 2013:616197.

M. F. Abdul-Wahab, T. Homma, M. Wright, D. Olerenshaw, T. R. Dafforn, K. Nagata, & A. D. Miller, The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster, J. Biol. Chem., 2013, 288, 4452

X. Chen, N. Boonyalai, C. Lau, S. Thipayang, Y. Xu, M. Wright & A. D. Miller, Multiple catalytic activities of Escherichia coli lysyl-tRNA synthetase (LysU) are dissected by site directed mutagenesis, FEBS J., 2013, 280, 102

N. Boonyalai, J. R. Pullen, M. F. Abdul-Wahab, M. Wright & A. D. Miller, Escherichia coli LysU is a potential surrogate for human lysyl tRNA synthetase in interactions with the C-terminal domain of HIV-1 capsid protein, Org. Biomol. Chem., 2013, 11, 612

J. R. Pullen, J. Dalmaris, S. A. Serapian, A. D. Miller, Assessing the preferred solution conformation of an interacting sense-antisense (complementary) peptide pair, Bioorg. Med. Chem. Lett., 2013, 23, 496

M. Wright & A. D. Miller, Quantification of diadenosine polyphosphates in blood plasma using a tandem boronate affinity-ion exchange chromatography system, Anal. Biochem., 2013, 432, 103

S. Kolli, S.-P. Wong, R. Harbottle, B. Johnston, M. Thanou & A. D. Miller, pH-Triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo, Bioconjugate Chem., 2013, 24, 314

P. Yingyuad, M. Mével, C. Prata, S. Furegati, C. Kontogiorgis, M. Thanou & A. D. Miller, Enzyme-triggered PEGylated pDNA-nanoparticles for controlled release of pDNA in tumours, Bioconjugate Chem., 2013, 24, 343

C. R. Drake, A. Aissaoui, O. Argyros, M. Thanou, J. H. G. Steinke & A. D. Miller, Examination of the effect of increasing the number of intra-disulfide amino functional groups on the performance of small molecule cyclic polyamine disulfide vectors, J. Control. Rel., 2013, 171, 81

A. D. Miller, Lipid-based nanoparticles in cancer diagnosis and therapy, J. Drug Del., 2013, 165981

J. Bai, Y. J. Liu, W. Q. Sun, J. Chen, A. D. Miller & Y. H. Xu, Down-regulated lysosomal processing improved PEGylated lipopolyplex-mediated gene transfection, J. Gene Med., 2013, 15, 182

M. Wang, A. D. Miller, M. Thanou, Effect of surface charge and ligand organization on the specific cell-uptake of uPAR-targeted nanoparticles, J. Drug Target., 2013, 21, 684

A. D. Miller, Delivery of RNAi therapeutics: work in progress, Expert Rev. Med. Dev., 2013, 10, 781

M. Křupka, J. Mašek, E. Bartheldyová, P. Turánek-Knotigová, J. Plocková, Z. Korvasová, M. Škrabalová, Š. Koudelka, P. Kulich, K. Zachová, L. Czerneková, O. Strouhal, M. Horynová, M. Šebela, A. D. Miller, M. Ledvina, M. Raška & J. Turánek, Enhancement of immune response towards non-lipidized Borrelia burgdorferi recombinant OspC antigen by binding onto the surface of metallochelating nanoliposomes with entrapped lipophilic derivatives of norAbuMDP, J. Control. Rel., 2012, 160, 374

J. Mašek, E. Bartheldyová, P. Turánek-Knotigová, M. Škrabalová, Z. Korvasová, J. Plocková, Š. Koudelka, P. Škodová, P. Kulich, M. Křupka, K. Zachová, L. Czerneková, M. Horynová, I. Kratochvílová, A. D. Miller, D. Zýka, J. Michálek, J. Vrbková, M. Šebela, M. Ledvina, M. Raška & J. Turánek, Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged antigens: preparation, structural study and immune response towards rHsp90, J. Control. Rel., 2011, 151, 193

A. Aissaoui, M. Chami, M. Hussein & A. D. Miller, Efficient topical delivery of plasmid DNA to lung in vivo mediated by putative triggered, PEGylated pDNA nanoparticles, J. Control. Rel., 2011, 154, 275

G. D. Kenny, N. Kamaly, T. L. Kalber, L. P. Brody, M. Sahuri, E. Shamsaei, A. D. Miller & J. D. Bell, Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo, J. Control. Rel., 2011, 149, 111

J. Mašek, E. Bartheldyová, Z. Korvasová, M. Škrabalová, S. Koudelka, P. Kulich, I. Kratochvílová, A. D. Miller, M. Ledvina, M. Raška & J. Turánek, Immobilization of histidine-tagged proteins on monodisperse metallochelation liposomes: preparation and study of their structure, Anal. Biochem., 2011, 408, 95

Dick EA & Gedroyc WM., ExAblate magnetic resonance-guided focused ultrasound system in multiple body applications. Expert Rev Med Devices. 2010 Sep;7(5):589-97.

C. R. Drake, A. Aissaoui, O. Argyros, J. M. Serginson, B. D. Monnery, M. Thanou, J. H. G. Steinke & A. D. Miller, Bioresponsive small molecule polyamines as noncytotoxic alternative to polyethylenimine, Mol. Pharmaceutics, 2010, 7, 2040

N. Kamaly, J. A. Pugh, T. L. Kalber, J. Bunch, A. D. Miller, C. W. McLeod  & J. D. Bell, Imaging of gadolinium spatial distribution in tumour tissue by laser ablation inductively coupled plasma mass-spectrometry, Mol. Imaging Biol., 2010, 12, 361

N. Kamaly, T. L. Kalber, G. D. Kenny, J. D. Bell, M. R. Jorgensen & A. D. Miller, A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI, Org. Biomol. Chem., 2010, 8, 201

M. Mével, N. Kamaly, S. Carmona, M. H. Oliver, M. R. Jorgensen, C. Crowther, F. H. Salazar, P. L. Marion, M. Fujino, Y. Natori, M. Thanou, P. Arbuthnot, J.-J. Yaouanc, P. A. Jaffres, & A. D. Miller, DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA, J. Control. Rel., 2010, 143, 222

Y. Bhurruth-Alcor, T. H. Røst, M. R. Jorgensen, Rajender, M. Müller, J. Skorve, R. K. Berge & A. D. Miller, Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR selective, Bioorg. Med. Chem. Lett., 2010, 20, 1252

N. Kamaly, A. D. Miller & J. D. Bell, Chemistry of tumour targeted T1 based MRI contrast agents, Curr. Topics Med. Chem., 2010, 10, 1158

S. Carmona, M. R. Jorgensen, S. Kolli, C. Crowther, F. H. Salazar, P. L., Marion, M.  Fujino, Y. Natori, M. Thanou, P. Arbuthnot & A. D. Miller, Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA nanoparticles, Mol. Pharmaceutics, 2009, 6, 706

M. R. Jorgensen, Y. Bhurruth-Alcor, T. Røst, P. Bohov, M. Müller, C. Guisado, K. Kostarelos, E. Dyrøy, R. K. Berge, A. D. Miller & J. Skorve, Synthesis and analysis of novel glycerolipids for the treatment of metabolic syndrome, J. Med. Chem., 2009, 52, 1172

S. Song, D. Liu, J. Peng, H. Deng, Y. Guo, L. X. Xu, A. D. Miller & Y. Xu, Novel peptide ligand directs liposomes toward EGF-R high-expressing cancer cells in vitro and in vivo, FASEB J., 2009, 23, 1396

N. Kamaly, T. Kalber, M. Thanou, J. D. Bell & A. D. Miller, Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging, Bioconjugate Chem., 2009, 20, 648

D. Boraschi, A. Tagliabue & A. D. Miller, The immunostimulatory effect of IL-1 in vivo is blocked by antisense peptides complementary to the loop sequence 163-171, FEBS Lett., 2009, 583, 792

O. Argyros, S.-P. Wong, M. Niceta, S. N. Waddington,  S. J. Howe, C. Coutelle, A. D. Miller & R. P. Harbottle, Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing  non-viral vector, Gene Ther., 2008, 15, 1593

A. Andreu, N. Fairweather & A. D. Miller, Clostridium neurotoxin fragments as potential targeting moieties for liposomal gene delivery to the CNS, ChemBioChem, 2008, 9, 219

N. Kamaly, T. Kalber, A. Ahmad, M. H. Oliver, P.-W. So, A. H. Herlihy, J. D. Bell, M. R. Jorgensen & A. D. Miller, Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging, Bioconjugate Chem., 2008, 19, 118

S. Fletcher, A. Ahmad, W. S. Price, M. R. Jorgensen & A. D. Miller, Biophysical properties of CDAN/DOPE-analogue lipoplexes account for enhanced gene delivery, ChemBioChem, 2008, 9, 455

M. Wright, N. Boonyalai, J. A. Tanner, A. D. Hindley & A. D. Miller, The duality of LysU, a catalyst for both Ap4A and Ap3A formation, FEBS J., 2006, 273, 3534

S. Melnik, M. Wright, J. A. Tanner, T. Tsintsadze, V. Tsintsadze, A. D. Miller & N. Lozovaya, Diadenosine polyphosphate analog controls postsynaptic excitation in CA3-CA1 synapses via a nitric oxide-dependent mechanism, J. Pharmacol. Exp. Ther., 2006, 318, 579

J. A. Tanner, M. Wright, E. M. Christie, M. K. Preuss & A. D. Miller, Investigation into the interactions between diadenosine 5’, 5’”-P1, P4-tetraphosphate and two proteins: molecular chaperone groEL and cAMP receptor protein, Biochemistry, 2006, 45, 3095

S. Fletcher, A. Ahmad, E. Perouzel, M. R. Jorgensen & A. D. Miller, A dialkynoyl analogue of DOPE improves gene transfer efficiency of lower-charged, cationic lipoplexes, Org. Biomol. Chem., 2006, 4, 196

S. Fletcher, A. Ahmad, E. Perouzel, A. Heron, A. D. Miller & M. R. Jorgensen, In vivo studies of dialkynoyl analogues of DOTAP demonstrate improved gene transfer efficiency of cationic liposomes in mouse lung, J. Med. Chem., 2006, 49, 349

J. E. Waterhouse, R. P. Harbottle, M. Keller, K. Kostarelos, C. Coutelle, M. R. Jorgensen & A. D. Miller, Synthesis and application of integrin targeting lipopeptides in targeted gene delivery, ChemBioChem, 2005, 6, 1212

K. Kostarelos & A. D. Miller, Synthetic, self-assembly ABCD nanoparticles; structural paradigm for viable synthetic non-viral vectors, Chem. Soc. Rev., 2005, 34, 970